Document Detail


Management of oesophageal stenosis in epidermolysis bullosa dystrophica.
MedLine Citation:
PMID:  2751329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven patients with epidermolysis bullosa dystrophica and chronic and recurrent oesophageal lesions such as spasm, strictures, and complete occlusion were studied. Dysphagia could be cured with drugs if it was caused by bullae formation or spasm. If oesophageal strictures were present, endoscopy and bouginage with corticosteroid prophylaxis during the quiescent phase of the disease was a safe and useful procedure. We have also given corticosteroids, which reduced the oedema caused by bullae formation and oral phenytoin, which reduced epithelial detachment by inhibiting collagenase activity. Verapamil counteracted oesophageal spasm and pureed food during periods of dysphagia reduced blistering of the upper oesophagus.
Authors:
I B Kern; M Eisenberg; S Willis
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  64     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-18     Completed Date:  1989-08-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  551-6     Citation Subset:  AIM; IM    
Affiliation:
Prince of Wales Children's Hospital, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenal Cortex Hormones / therapeutic use
Child
Child, Preschool
Deglutition Disorders / etiology,  therapy
Dilatation
Epidermolysis Bullosa / complications*
Esophageal Stenosis / etiology,  therapy*
Female
Humans
Male
Phenytoin / therapeutic use
Verapamil / therapeutic use
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 52-53-9/Verapamil; 57-41-0/Phenytoin
Comments/Corrections

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