Document Detail


Management of neonatal aortic arch thrombosis with low-molecular weight heparin: a case series.
MedLine Citation:
PMID:  19564749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aortic arch thrombosis (AAT) is a potentially life threatening condition in neonates. We report 3 neonates with AAT and complete occlusion of a unilateral internal carotid artery with multiple cerebral infarcts. Multidisciplinary input led to deferral of thrombolytic therapy and surgical thrombectomy owing to the potential risk of hemorrhage within the infarcts. All the neonates were treated with low-molecular weight heparin treatment alone without any complications. Thrombus resolution was complete in 2 neonates, whereas it was near complete in one neonate. All the infants showed normal growth and development during follow-up. The rewarding outcome in these cases suggests that treatment with low-molecular weight heparin could be considered an option to treat AAT in selected patients.
Authors:
Anjali Alatkar Sharathkumar; Nancy Lamear; Steven Pipe; Sanjay Parikh; Mark Russell; Abrahim Simon; Amy Shapiro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  31     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-07-15     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  516-21     Citation Subset:  IM    
Affiliation:
Indiana Hemophilia and Thrombosis Centre, St Vincent Women's Hospital parallelChildren's Heart Center, St Vincent Hospitals, Indianapolis, IN 46260, USA. asharathkumar@ihtc.org
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / therapeutic use*
Aorta, Thoracic / pathology*
Aortic Diseases / complications,  drug therapy*
Carotid Artery Diseases / drug therapy,  pathology
Cerebral Infarction / drug therapy,  etiology
Heparin, Low-Molecular-Weight / therapeutic use*
Humans
Infant, Newborn
Thrombosis / complications,  drug therapy*,  pathology*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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