| Management of multiple-antibody-mediated hyperthyroidism in children with Down's syndrome. | |
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MedLine Citation:
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PMID: 9076303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During a period of 7 years at our institution, four girls and one boy with Down's syndrome, ages 9 to 16 years, were examined and treated for hyperthyroidism. Two patients had Graves' disease and they responded to propylthiouracil (PTU) with a predictable clinical course resulting in remission within 4 years. The remaining three patients included in this report had hyperthyroid profiles similar to those of the two with Graves' disease except for their antibody panels. These patients, in addition to the elevated thyroid-stimulating immunoglobulin (TSI) level observed in Graves' disease, also had significantly elevated antimicrosomal antibody (AMA) and antithyroglobulin antibody (ATGA) at the time of diagnosis. Elevated TSI level was again present in two patients who had a recurrence of hyperthyroidism after PTU therapy was discontinued. Treatment of these three patients was best done with the continuation of PTU therapy at a lower dose and the addition of thyroxine as soon as mild hypothyroidism developed. Treatment with PTU and thyroxine was continued until the TSI level was no longer elevated. Levels of AMA and ATGA remained elevated long after the TSI level became normal. All three patients eventually had hypothyroidism and continue to require thyroxine replacement. |
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Authors:
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S K Bhowmick; P H Grubb |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 90 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-04-17 Completed Date: 1997-04-17 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 312-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, US Air Force Medical Center, Keesler AFB, Miss 39534-2519, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antithyroid Agents / administration & dosage, therapeutic use Autoantibodies / analysis* Child Down Syndrome / complications* Female Graves Disease / complications, drug therapy Humans Hyperthyroidism / complications, drug therapy*, immunology Hypothyroidism / drug therapy, etiology Immunoglobulins, Thyroid-Stimulating / analysis* Male Microsomes / immunology* Propylthiouracil / administration & dosage, therapeutic use Recurrence Remission Induction Thyroglobulin / immunology* Thyroxine / administration & dosage, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 0/Autoantibodies; 0/Immunoglobulins, Thyroid-Stimulating; 0/anti-thyroglobulin; 51-52-5/Propylthiouracil; 7488-70-2/Thyroxine; 9010-34-8/Thyroglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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