| Management of mitochondrial stroke-like-episodes. | |
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MedLine Citation:
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PMID: 19780807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aim of this review is to discuss recent findings concerning the management of stroke-like episodes (SLEs) in patients with mitochondrial disorders (MIDs). Various databases were searched for appropriate literature. SLEs are a dominant feature of MIDs and occur most frequently in MELAS-syndrome, less frequently in MERRF-syndrome, Kearns-Sayre-syndrome, or Leigh-syndrome. SLEs occur at all ages and are frequently accompanied by other cerebral abnormalities. Clinically, SLEs mimic ischemic stroke but not on imaging studies and concerning the management. The morphological equivalent on MRI is the stroke-like-lesion, representing a vasogenic edema (hyperintensity on T2, diffusion-weighted imaging and apparent diffusion coefficient in the acute and subacute or chronic stage, most frequently in the parieto-occipital region, surpassing vascular territories). For diagnostic and therapeutic reasons SLEs need to be clearly delineated from ischemic stroke and cerebral bleeding. Though there is no causal therapy available, symptomatic and general measures can help to resolve the clinical manifestations. In conclusion this review shows that SLEs are a dominant feature of some syndromic or non-syndromic MIDs. The most effective strategy for the treatment of SLEs appears to be the application of L-arginine, coenzyme-Q, steroids, edaravone, creatine-monohydrate, or dichloracetate. |
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Authors:
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J Finsterer |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-09-23 |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 16 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-21 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 1178-84 Citation Subset: IM |
Affiliation:
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Krankenanstalt Rudolfstiftung, Vienna and Danube University, Krems, Austria. fifigs1@yahoo.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology Brain Diseases, Metabolic, Inborn / complications, diagnosis*, pathology, therapy* Diagnosis, Differential Humans Magnetic Resonance Imaging Mitochondria / pathology Stroke / complications, diagnosis*, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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