Document Detail

Management of membranoproliferative glomerulonephritis type II with plasmapheresis.
MedLine Citation:
PMID:  12378549     Owner:  NLM     Status:  MEDLINE    
Membranoproliferative glomerulonephritis type II (MPGN II) is a rare kidney disease identified microscopically by electron-dense deposits surrounded by complement component C3 in glomerular basement membranes. MPGN II usually leads to renal failure, and patients with MPGN II experience a high rate of recurrence following renal transplantation. No treatment modalities have been proven successful if recurrence does occur. The sera of most patients with MPGN II contain complement C3 nephritic factor (C3NF), an IgG autoantibody directed against C3 convertase (C3bBb) that results in constitutive breakdown of C3. C3NF may be important in the pathogenesis of the disease. Since C3NF is IgG, we predicted that C3NF could be removed from the serum through plasmapheresis. We describe the use of long-term plasmapheresis to maintain good renal function in a 15-year-old girl with rapidly progressive recurrent MPGN II. After 73 plasmapheresis procedures over 63 weeks, her serum creatinine remained stable, and her creatinine clearance trended upward. Serial biopsies of the transplanted kidney demonstrated persistent MPGN II but no development of tubular atrophy. During the course of therapy, serum C3NF activity decreased; furthermore, C3NF activity was detected in the removed plasma. We have shown that plasmapheresis is a safe and effective method for delaying the onset of chronic renal failure in recurrent MPGN II. The efficacy may be due to the removal of serum C3NF.
Kevin A Kurtz; Annette J Schlueter
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  17     ISSN:  0733-2459     ISO Abbreviation:  J Clin Apher     Publication Date:  2002  
Date Detail:
Created Date:  2002-10-14     Completed Date:  2003-03-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
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MeSH Terms
Complement C3 Nephritic Factor / isolation & purification
Glomerulonephritis, Membranoproliferative / therapy*
Reg. No./Substance:
0/Complement C3 Nephritic Factor

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