Document Detail


Management of locally advanced cervical cancer in pregnancy: a case report.
MedLine Citation:
PMID:  20968145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Carcinoma of the cervix is the most common malignancy associated with pregnancy. In the first and second trimesters patients should receive the same treatment as is used in nonpregnant women and termination is advised. In selected cases neoadjuvant chemotherapy (NACT) could be proposed but only a few cases have been reported. CASE: A 27-year-old woman, gravida 1 para 0, at 15 weeks' gestation, was diagnosed with FIGO stage IB2 squamous cervical cancer. After refusing to terminate pregnancy, she was treated with neoadjuvant chemotherapy (cisplatin) starting at 18 weeks. A cesarean section with radical surgery was performed at 32 weeks and a healthy baby delivered. Four weeks later the patient started chemoradiation therapy. She relapsed 1 year after surgery and died when her child was 2 years old. CONCLUSION: NACT followed by radical surgery was an unsuccessful treatment in our patient; platinum-based chemotherapy was harmless to the child up to the last follow-up.
Authors:
Emanuela Rabaiotti; Cristina Sigismondi; Serena Montoli; Giorgia Mangili; Massimo Candiani; Riccardo Viganò
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  96     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-10-25     Completed Date:  2010-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  623-6     Citation Subset:  IM    
Affiliation:
Obstetrics and Gynecology Department, IRCCS Ospedale San Raffaele, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents / therapeutic use*
Carcinoma, Squamous Cell / pathology,  therapy*
Cesarean Section
Chemotherapy, Adjuvant
Cisplatin / therapeutic use*
Female
Humans
Hysterectomy*
Neoadjuvant Therapy / methods*
Pregnancy
Pregnancy Complications, Neoplastic / pathology,  therapy*
Pregnancy Outcome
Pregnancy Trimester, First
Radiotherapy, Adjuvant
Treatment Outcome
Uterine Cervical Neoplasms / pathology,  therapy*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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