| Management of locally advanced cervical cancer in pregnancy: a case report. | |
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MedLine Citation:
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PMID: 20968145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Carcinoma of the cervix is the most common malignancy associated with pregnancy. In the first and second trimesters patients should receive the same treatment as is used in nonpregnant women and termination is advised. In selected cases neoadjuvant chemotherapy (NACT) could be proposed but only a few cases have been reported. CASE: A 27-year-old woman, gravida 1 para 0, at 15 weeks' gestation, was diagnosed with FIGO stage IB2 squamous cervical cancer. After refusing to terminate pregnancy, she was treated with neoadjuvant chemotherapy (cisplatin) starting at 18 weeks. A cesarean section with radical surgery was performed at 32 weeks and a healthy baby delivered. Four weeks later the patient started chemoradiation therapy. She relapsed 1 year after surgery and died when her child was 2 years old. CONCLUSION: NACT followed by radical surgery was an unsuccessful treatment in our patient; platinum-based chemotherapy was harmless to the child up to the last follow-up. |
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Authors:
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Emanuela Rabaiotti; Cristina Sigismondi; Serena Montoli; Giorgia Mangili; Massimo Candiani; Riccardo Viganò |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Tumori Volume: 96 ISSN: 0300-8916 ISO Abbreviation: Tumori Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0111356 Medline TA: Tumori Country: Italy |
Other Details:
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Languages: eng Pagination: 623-6 Citation Subset: IM |
Affiliation:
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Obstetrics and Gynecology Department, IRCCS Ospedale San Raffaele, Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / therapeutic use* Carcinoma, Squamous Cell / pathology, therapy* Cesarean Section Chemotherapy, Adjuvant Cisplatin / therapeutic use* Female Humans Hysterectomy* Neoadjuvant Therapy / methods* Pregnancy Pregnancy Complications, Neoplastic / pathology, therapy* Pregnancy Outcome Pregnancy Trimester, First Radiotherapy, Adjuvant Treatment Outcome Uterine Cervical Neoplasms / pathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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