Document Detail

Management of infertility in a patient presenting with ovarian dysfunction and McCune-Albright syndrome.
MedLine Citation:
PMID:  15001590     Owner:  NLM     Status:  MEDLINE    
Persistent autonomous ovarian dysfunction in McCune-Albright syndrome (MAS) patients is associated with the development of multiple dominant follicles, premature luteinization, cyst formation, and anovulatory infertility. Due to the mosaic distribution of the mutation, ovaries may be unequally affected. In the current patient, the least affected ovary became quiescent upon GnRH agonist-induced gonadotropin suppression. Normoovulatory cycles were restored after subsequent removal of the affected right ovary, and a pregnancy was established within 3 months. A healthy unaffected girl was born at term after an uneventful pregnancy. The placental tissue was normal, and the mutation was not detected in the placenta, umbilical cord structures, or umbilical cord blood. GnRH analog administration may help to identify those MAS patients who might benefit from unilateral ovariectomy. Because a healthy baby was born, evidence is provided suggesting that MAS is not passed on to the children from the parents.
Joop S E Laven; Serge Lumbroso; Charles Sultan; Bart C J M Fauser
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-05     Completed Date:  2004-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1076-8     Citation Subset:  AIM; IM    
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.
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MeSH Terms
Endometrium / physiopathology
Fibrous Dysplasia, Polyostotic / complications*,  genetics
Gonadotropin-Releasing Hormone / genetics
Infertility, Female / etiology*,  physiopathology,  surgery*
Ovary / physiopathology*
Pregnancy Outcome
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone

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