Document Detail

Management of infections related to totally implantable venous-access ports: challenges and perspectives.
MedLine Citation:
PMID:  24314751     Owner:  NLM     Status:  MEDLINE    
Use of totally implantable venous-access ports (TIVAPs) is standard practice for patients with diseases such as solid-tumour cancers, haematological malignancies, and chronic digestive diseases. Use of TIVAPs allows long-term administration of venotoxic compounds, improves patients' quality of life, and reduces the risk of infection. Microbial contamination, formation of pathogenic biofilms, and infection, however, are associated with morbidity, mortality, and increased health-care costs. Local and systemic complications or infections related to specific pathogens might lead to device removal. Alternatively, conservative treatment with combined systemic antibiotics and antibiotic lock therapy might be useful. We discuss in-vitro and in-vivo basic and clinical research findings on the epidemiology, diagnosis, and prevention of TIVAP-related infections, the current challenges to management, promising strategies, and some treatments in development that are likely to improve outcomes of TIVAP-related infections, with a particular focus on antibiotic lock therapy.
David Lebeaux; Nuria Fernández-Hidalgo; Ashwini Chauhan; Samuel Lee; Jean-Marc Ghigo; Benito Almirante; Christophe Beloin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-12-05
Journal Detail:
Title:  The Lancet. Infectious diseases     Volume:  14     ISSN:  1474-4457     ISO Abbreviation:  Lancet Infect Dis     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-01-24     Completed Date:  2014-03-17     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101130150     Medline TA:  Lancet Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  146-59     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Bacteremia / diagnosis,  etiology,  therapy
Candidemia / diagnosis,  etiology,  therapy
Catheter-Related Infections / diagnosis,  etiology,  therapy*
Catheterization, Central Venous / instrumentation*,  methods
Catheters, Indwelling / adverse effects*
Device Removal
Risk Factors
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
Lancet Infect Dis. 2014 Aug;14(8):676-7   [PMID:  25056015 ]
Lancet Infect Dis. 2014 Aug;14(8):676   [PMID:  25056016 ]

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