Document Detail


Management of hyperthyroidism during pregnancy and lactation.
MedLine Citation:
PMID:  21389085     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction: Poorly treated or untreated maternal overt hyperthyroidism may affect pregnancy outcome. Fetal and neonatal hypo- or hyperthyroidism and neonatal central hypothyroidism may complete health issues during intrauterine and neonatal periods. Aim: To review articles related to appropriate management of hyperthyroidism during pregnancy and lactation. Methods: A literature review was performed using MEDINE with the terms "hyperthyroidism and pregnancy", "antithyroid drugs and pregnancy", "radioiodine and pregnancy", "hyperthyroidism and lactation", "antithyroid drugs and lactation", both separately and in conjunction with the terms "fetus", and "maternal". Results: Antithyroid drugs are the main therapy for maternal hyperthyroidism. Both methimazole (MMI) and propylthiouracil (PTU) may be used during pregnancy; however, PTU is preferred in the first trimester and should be replaced by MMI after this trimester. Choanal and esophageal atresia of fetus in MMI-treated and maternal hepatotoxicity in PTU-treated pregnancies are of utmost concern. Maintaining free T4 concentration in the upper one third of the normal range denotes success of therapy. Methimazole is the mainstay of the treatment of postpartum hyperthyroidism, in particular during lactation. Conclusion: Management of hyperthyroidism during pregnancy and lactation requires special considerations and should be carefully implemented to avoid any adverse effects on the mother, fetus and neonate.
Authors:
Fereidoun Azizi; Atieh Amouzegar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-9
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
F Azizi, Endocrine research Center, Shahid Beheshti University, Tehran, Iran, Islamic Republic of.
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