| Management of hydrocephalus in infancy: use of acetazolamide and furosemide to avoid cerebrospinal fluid shunts. | |
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MedLine Citation:
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PMID: 4009338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite its effectiveness, cerebrospinal shunting for hydrocephalus continues to be accompanied by considerable complications and morbidity. Medical therapy with acetazolamide 100 mg/kg/day and furosemide 1 mg/kg/day can be an effective alternative to shunting by halting progression of hydrocephalus until such time as sutures can become fibrosed and spontaneous arrest can occur. In an appropriately selected population older than 2 weeks with hydrocephalus of varied origin, our success rate in avoiding shunting is greater than 50%. The dramatic difference between the number of hospitalizations of patients with shunts and those treated medically, and the potential to avoid shunt dependence would appear to make an initial trial with medical therapy worthwhile. |
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Authors:
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S Shinnar; K Gammon; E W Bergman; M Epstein; J M Freeman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 107 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-16 Completed Date: 1985-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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administration & dosage*,
adverse effects Acid-Base Imbalance / chemically induced Age Factors Cerebrospinal Fluid Shunts / adverse effects Drug Therapy, Combination Follow-Up Studies Furosemide / administration & dosage*, adverse effects Humans Hydrocephalus / drug therapy*, etiology, surgery Infant Infant, Newborn Length of Stay |
| Chemical | |
Reg. No./Substance:
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54-31-9/Furosemide; 59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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