| Management of heparin-associated thrombocytopenia in pregnancy with subcutaneous r-hirudin. | |
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MedLine Citation:
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PMID: 10629377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparin-induced thrombocytopenia type II is a serious, immune-mediated complication of heparin therapy. Due to its low cross-reactivity with heparin-associated antibodies (10-20%), danaparoid has successfully been administered in these patients. In recent studies, r-hirudin as a potent and specific thrombin inhibitor, was demonstrated to be a safe and effective anticoagulant. We report a pregnant woman with systemic lupus erythematosus and recurrent venous thromboembolism who suffered from heparin-induced thrombocytopenia type II while treated with dalteparin sodium. Positive cross-reactivities with danaparoid were found. Anticoagulation with 15 mg subcutaneous r-hirudin was performed twice daily from the 25th week of pregnancy until delivery. No thromboembolism or bleeding or fetal toxicity of r-hirudin was detected. Recombinant hirudin is a potent and specific thrombin inhibitor that can be used as a safe and effective anticoagulant in pregnancy. |
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Authors:
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G Huhle; M Geberth; U Hoffmann; D L Heene; J Harenberg |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 49 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2000 |
Date Detail:
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Created Date: 2000-02-04 Completed Date: 2000-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 67-9 Citation Subset: IM |
Copyright Information:
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Copyright 2000 S. Karger AG, Basel |
Affiliation:
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1st Department of Medicine, Faculty of Clinical Medicine Mannheim, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticoagulants / adverse effects Antithrombins / therapeutic use* Dalteparin / adverse effects Female Heparin / adverse effects* Hirudin Therapy* Humans Lupus Erythematosus, Systemic / complications Pregnancy Pregnancy Complications, Cardiovascular* Recombinant Proteins / therapeutic use Thrombocytopenia / chemically induced*, drug therapy*, immunology Venous Thrombosis / complications, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Antithrombins; 0/Dalteparin; 0/Recombinant Proteins; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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