Document Detail


Management of genital warts in women with human leukocyte interferon-alpha vs. podophyllotoxin in cream: a placebo-controlled, double-blind, comparative study.
MedLine Citation:
PMID:  7670929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this double-blind, placebo-controlled, comparative study was to evaluate the specific clinical efficacy and tolerance of human leukocyte interferon-alpha (2 x 10(6) IU/g) and podophyllotoxin 0.5% incorporated in a hydrophilic cream to cure genital warts. Preselected Asian women (n = 60) aged 18-40 years (mean 22.9), with a clinical and biopsy-confirmed diagnosis of genital warts, harboring 322 lesions (mean 5.36) were randomly assigned to three parallel groups to receive one of the two test drugs or placebo. Each patient received a precoded tube (40 g) containing either human leukocyte interferon-alpha, podophyllotoxin, or identically appearing placebo cream for 3 days' usage. In addition to written instructions, each subject was shown how to apply a minimal amount of trial medication on their lesions thrice daily for 3 consecutive days per week (maximum nine topical applications per week). Patients were examined on a weekly basis, and a cure was considered to be a biopsy-confirmed, total elimination of a lesion. Moreover, patients cured during the study period were spared further therapy, and were requested to return in 16 weeks to monitor for the occurrence of a relapse. The remaining patients' empty tubes were collected, and similarly precoded replacement tubes were given to continue the treatment; a total of 214 tubes were used. The study was scheduled for 16 weeks with 4 weeks of active treatment. Individuals were excluded from the study due to pregnancy, breast feeding, or the receiving of any type of antiviral therapy during the 4 weeks preceding enrollment.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
T A Syed; M Khayyami; D Kriz; K Svanberg; R C Kahlon; S A Ahmad; S A Ahmad
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  73     ISSN:  0946-2716     ISO Abbreviation:  J. Mol. Med.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2011-07-08    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  255-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology, University Hosptial Malmö, University of Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biopsy
Condylomata Acuminata / diagnosis,  drug therapy,  therapy*
Dosage Forms
Double-Blind Method
Female
Humans
Interferon-alpha / adverse effects,  therapeutic use*
Placebo Effect
Podophyllotoxin / adverse effects,  therapeutic use*
Vulvar Diseases / diagnosis,  drug therapy,  therapy*
Chemical
Reg. No./Substance:
0/Dosage Forms; 0/Interferon-alpha; 518-28-5/Podophyllotoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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