Document Detail

Management of gastropathy and gastric vascular ectasia in portal hypertension.
MedLine Citation:
PMID:  20682235     Owner:  NLM     Status:  MEDLINE    
Portal hypertensive gastropathy and gastric antral vascular ectasia may cause gastrointestinal hemorrhage in patients with portal hypertension. Whereas the former presents exclusively in patients with portal hypertension, gastric antral vascular ectasia can also be observed in patients with other conditions. Diagnosis is established with upper gastrointestinal endoscopy, although some cases may require a biopsy to confirm the diagnosis. The most frequent manifestation is ferropenic anemia, which may become transfusion dependent. Treatment in portal hypertensive gastropathy is focused on portal pressure reducing drugs, mainly nonselective beta-blockers, whereas in gastric antral vascular ectasia treatment is based on endoscopic ablation. More invasive options can be used if first-line therapies fail, although these should be evaluated on a case-by-case basis.
Cristina Ripoll; Guadalupe Garcia-Tsao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in liver disease     Volume:  14     ISSN:  1557-8224     ISO Abbreviation:  Clin Liver Dis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-12-20     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281-95     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Ablation Techniques / adverse effects,  methods
Adrenergic beta-Antagonists / therapeutic use
Anemia, Iron-Deficiency / blood,  etiology,  physiopathology,  therapy
Biopsy / adverse effects,  methods
Blood Transfusion
Endoscopes, Gastrointestinal*
Gastric Antral Vascular Ectasia* / diagnosis,  etiology,  physiopathology,  therapy
Gastrointestinal Hemorrhage* / diagnosis,  etiology,  physiopathology,  therapy
Hypertension, Portal / diagnosis*,  etiology,  physiopathology,  therapy*
Liver Cirrhosis / complications,  physiopathology
Stomach Diseases* / diagnosis,  etiology,  physiopathology,  therapy
Treatment Outcome
Grant Support
K24 DK002727/DK/NIDDK NIH HHS; K24 DK002727-01/DK/NIDDK NIH HHS; P30 DK034989/DK/NIDDK NIH HHS; P30 DK034989-219005/DK/NIDDK NIH HHS; P30 DK34989/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Adrenergic beta-Antagonists

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