Document Detail

Management of fungal infection in neutropenic patients with fluconazole.
MedLine Citation:
PMID:  2182447     Owner:  NLM     Status:  MEDLINE    
Fluconazole is a new orally absorbed antifungal azole which is effective in the treatment of mucosal and systemic infections caused by Candida, cryptococci and other fungi. In view of its favourable efficacy, safety and pharmacokinetic profile it was considered appropriate to evaluate its use prophylactically in patients undergoing a period of neutropenia. Two hundred and forty-eight patients receiving chemotherapy and/or bone marrow transplantation for the treatment of acute leukaemia, lymphoma or aplastic anaemia, and expected to be rendered temporarily neutropenic, have been entered into an ongoing multicentre comparative clinical study to compare the prophylactic efficacy of 50 mg daily oral fluconazole with that of widely used regimens of oral polyenes. The incidence of suspected fungal infection was less in the fluconazole group (27%) than in the polyene group (45%), the difference being statistically significant (P less than 0.05). Only one of the suspected infections in the fluconazole group was confirmed mycologically compared with 17 in the polyene group. Fluconazole prophylaxis was well tolerated and it therefore offers a promising new approach to the management of fungal infection in the neutropenic patient. Further studies are warranted to define the optimum dosage for use in this situation.
K W Brammer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Haematology and blood transfusion     Volume:  33     ISSN:  0171-7111     ISO Abbreviation:  Haematol Blood Transfus     Publication Date:  1990  
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101169459     Medline TA:  Haematol Blood Transfus     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  546-50     Citation Subset:  IM    
Clinical Research Department, Pfizer Central Research, Sandwich, Kent, UK.
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MeSH Terms
Agranulocytosis / complications*
Antifungal Agents / therapeutic use
Antineoplastic Agents / adverse effects
Fluconazole / therapeutic use*
Hematologic Diseases / complications,  therapy
Middle Aged
Multicenter Studies as Topic
Mycoses / drug therapy*,  etiology,  prevention & control
Neutropenia / complications*
Polyenes / therapeutic use
Radiotherapy / adverse effects
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Antifungal Agents; 0/Antineoplastic Agents; 0/Polyenes; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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