| Management of failed thrombolysis after acute myocardial infarction: an overview of current treatment options. | |
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MedLine Citation:
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PMID: 17079034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombolytic therapy remains the most commonly administered revascularization strategy for patients with ST-elevation myocardial infarctions (STEMI). However, many patients fail to have patent arteries or ST-segment resolution after these therapies. Multiple strategies have been examined to treat these patients with "failed thrombolysis." We examined the existing medical literature regarding treatment of failed thrombolysis including strategies testing repeat thrombolytic therapy and rescue percutaneous coronary intervention. Additional, we reviewed the literature regarding the efficacy of transferring patient for rescue percutaneous intervention and coronary stenting. The impact of contemporary antiplatelet strategies, cardiogenic shock, and coronary bypass surgery was examined. Overall, the management of patients with acute STEMI in whom thrombolytic therapy failed remains a challenging problem. As a result, many different strategies are currently in use. Among these therapeutic interventions, rescue PCI with coronary stenting appears to be superior when it is done in a timely manner by an experienced center. |
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Authors:
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Cesar E Mendoza; Mehul R Bhatt; Salim Virani; Alan H Schob; Stewart Levine; Alexandre C Ferreira; Eduardo de Marchena |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-10-31 |
Journal Detail:
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Title: International journal of cardiology Volume: 114 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-01-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 291-9 Citation Subset: IM |
Affiliation:
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University of Miami, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Clinical Trials as Topic Coronary Artery Bypass Fibrinolytic Agents / therapeutic use* Humans Intra-Aortic Balloon Pumping Myocardial Infarction / drug therapy, therapy* Platelet Aggregation Inhibitors / therapeutic use Recurrence / prevention & control Retreatment Shock, Cardiogenic / etiology, therapy Stents Thrombolytic Therapy* / adverse effects Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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