| Management and evolution of cervical intraepithelial neoplasia during pregnancy and postpartum. | |
| | |
MedLine Citation:
|
PMID: 12128266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the evolution of cervical intraepithelial neoplasia (CIN), and to evaluate the safety of cytological and colposcopical surveillance of women with CIN during pregnancy. STUDY DESIGN: Ninety-eight women with antenatal cytological and/or colposcopical impression of CIN were followed up during pregnancy with cytology and colposcopy every 2 months. A cytological and colposcopical reevaluation 2 months postpartum was done, and large loop excision of the transformation zone (LLETZ) was performed if appropriate. Punch or loop biopsies were only taken if there was suspicion of microinvasion. RESULTS: In 14 of 39 (35.9%) and in 25 of 52 (48.1%) women with antenatal impression of CIN I and CIN II-III, respectively, there was postnatal impression of regression. Seven women with findings suspicious of microinvasion underwent small loop biopsies during pregnancy, but early stromal invasion (< 1 mm) was seen in just one case. There was one more case of microinvasion (1.5 mm) diagnosed postnatally in which the antenatal impression was of CIN III. 84.6% of the women with regression compared to 67.3% of the women with stable disease or progression had a vaginal delivery (P = 0.057). CONCLUSION: There is a considerable regression rate of CIN after pregnancy possibly attributable to the loss of the dysplastic cervical epithelium during cervical ripening and vaginal delivery. Frequent cytological and colposcopical evaluation seems to be safe. Small loop biopsies are recommended in cases of possible microinvasion. |
| | |
Authors:
|
Evangelos Paraskevaidis; George Koliopoulos; Sophia Kalantaridou; Lambrini Pappa; Iordanis Navrozoglou; Kostas Zikopoulos; Dimitrios E Lolis |
Related Documents
:
|
18084146 - Conservative treatment of cervical pregnancy with selective unilateral uterine artery e... 9662566 - Cervical spine abnormalities and instability with myelopathy in warfarin-related chondr... 18989126 - Pregnancy management after cervical surgery. 10664646 - Cervical ectopic pregnancy. diagnosis with endovaginal ultrasound examination and succe... 21388976 - Cardiac outcome of pregnancy in women with a pacemaker and women with untreated atriove... 8739336 - Neonatal and placental factors in relation to the mode of umbilical cord insertion. ste... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 104 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2002 Aug |
Date Detail:
|
Created Date: 2002-07-19 Completed Date: 2003-02-20 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 67-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics & Gynecology and Cytology Laboratory, Ioannina University Hospital, Ioannina, Greece. gkoliopoulos@aol.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cervical Intraepithelial Neoplasia
/
etiology,
pathology,
therapy* Colposcopy Delivery, Obstetric / methods Female Humans Papillomavirus Infections / diagnosis Perinatal Care / methods* Postpartum Period Pregnancy Pregnancy Complications, Neoplastic / etiology, pathology, therapy*, virology Tumor Virus Infections / diagnosis Uterine Cervical Neoplasms / etiology, therapy*, virology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effectiveness of spectral and color Doppler in predicting ovarian torsion. A prospective study.
Next Document: Sigmoid colon cancer during pregnancy.