| Management of diabetic small-fiber neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate. | |
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MedLine Citation:
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PMID: 21769070 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Agents used to treat symptoms of diabetic peripheral neuropathy (DPN) are only palliative, not disease modifying. Although studies of monotherapy with L-methylfolate, methylcobalamin, or pyridoxal 5'-phosphate suggest that each of these bioavailable B vitamins may reverse the pathophysiology and symptoms of DPN, data on the efficacy of this combination therapy are limited. Therefore, we assessed the efficacy of an oral combination of L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate for improving epidermal nerve fiber density (ENFD) in the lower extremity of patients with DPN. Eleven consecutive patients with type 2 diabetes with symptomatic DPN were assessed for ENFD at the calf by means of skin punch biopsy and then placed on twice daily oral-combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate. After approximately 6 months of treatment, patients underwent follow-up biopsy. At the end of their treatment, 73% of patients showed an increase in calf ENFD, and 82% of patients experienced both reduced frequency and intensity of paresthesias and/or dysesthesias. This preliminary study suggests that combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate increases ENFD in patients with DPN. |
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Authors:
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Allen M Jacobs; Dunlei Cheng |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reviews in neurological diseases Volume: 8 ISSN: 1949-4378 ISO Abbreviation: Rev Neurol Dis Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101223246 Medline TA: Rev Neurol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 39-47 Citation Subset: IM |
Affiliation:
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Allen M. Jacobs & Associates, Ltd., St. Louis, MO. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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