| Management of diabetic hypertensives. | |
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MedLine Citation:
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PMID: 22145142 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hypertension occurs twice as commonly in diabetics than in comparable nondiabetics. Patients with both disorders have a markedly higher risk for premature microvascular and macrovascular complications. Aggressive control of blood pressure (BP) reduces both micro- and macrovascular complications. In diabetic hypertensives, angiotensin converting enzyme inhibitors (ACEIs) are the first line in management of hypertension, and can be replaced by angiotensin II receptor blockers (ARBs) if patients are intolerant of them. Recent studies suggest ARBs to be on par with ACEI in reducing both macro- and microvascular risks. Adding both these agents may have a beneficial effect on proteinuria, but no extra macrovascular risk reduction. Thiazides can also be used as first line drugs, but are better used along with ACEI/ARBs. Beta-blockers [especially if the patient has coronary artery disease] and calcium channel blockers are used as second line add-on drugs. Multidrug regimens are commonly needed in diabetic hypertensives. Achieving the target BP of <130/80 is the priority rather than the drug combination used in order to arrest and prevent the progression of macro- and microvascular complications in diabetic hypertensives. |
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Authors:
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Jai Ganesh; Vijay Viswanathan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of endocrinology and metabolism Volume: 15 Suppl 4 ISSN: 2230-9500 ISO Abbreviation: Indian J Endocrinol Metab Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101555690 Medline TA: Indian J Endocrinol Metab Country: India |
Other Details:
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Languages: eng Pagination: S374-9 Citation Subset: - |
Affiliation:
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Department of Diabetology, M.V. Hospital for Diabetes, Prof. M. Viswanathan Diabetes Research Centre, WHO Collaborating Centre for Research, Education and Training in Diabetes, No.4, West Mada Church Street, Royapuram, Chennai, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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