| Management of dapsone poisoning complicated by methaemoglobinaemia. | |
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MedLine Citation:
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PMID: 2811676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The currently recommended dosage regimen for methylene blue (intermittent bolus dose) in the treatment of methaemoglobinaemia caused by dapsone is often inadequate. This is due to the long half-life of dapsone which provides a continuing oxidative stress that can cause a recurrence of clinically significant methaemoglobinaemia. Methylene blue infusion is effective, as demonstrated in an illustrative case report, and should be supported by repeated doses of activated charcoal to enhance dapsone elimination. The principles of treatment of methaemoglobinaemia due to dapsone can be applied to methaemoglobinaemia due to any agent producing prolonged oxidative stress. |
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Authors:
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A H Dawson; I M Whyte |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Medical toxicology and adverse drug experience Volume: 4 ISSN: 0112-5966 ISO Abbreviation: Med Toxicol Adverse Drug Exp Publication Date: 1989 Sep-Oct |
Date Detail:
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Created Date: 1989-12-07 Completed Date: 1989-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8709214 Medline TA: Med Toxicol Adverse Drug Exp Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 387-92 Citation Subset: IM |
Affiliation:
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Royal Newcastle Hospital, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dapsone / poisoning* Humans Male Methemoglobinemia / chemically induced* Methylene Blue / metabolism Reticulocytes / metabolism Sulfhemoglobin / metabolism |
| Chemical | |
Reg. No./Substance:
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61-73-4/Methylene Blue; 80-08-0/Dapsone; 9010-20-2/Sulfhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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