| Management of colorectal cancer in patients with inflammatory bowel disease. | |
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MedLine Citation:
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PMID: 23407916 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: This study evaluated the clinicopathological features and survival rates of patients with inflammatory bowel disease who developed colorectal cancer (CRC). METHODS: A retrospective review was performed on a prospectively maintained institutional database (1981-2011) to identify patients with inflammatory bowel disease who developed CRC. Clinicopathological parameters, management and outcomes were analysed. RESULTS: A total of 2,843 patients with inflammatory bowel disease were identified. One thousand six hundred and forty-two had ulcerative colitis (UC) and 1,201 had Crohn's disease (CD). Following exclusion criteria, there were 29 patients with biopsy-proven colorectal carcinoma, 22 of whom had UC and 7 had CD. Twenty-six patients had a preoperative diagnosis of malignancy/dysplasia; 16 of these were diagnosed at surveillance endoscopy. Nodal/distant metastasis was identified at presentation in 47 and 71 % of the UC and CD group, respectively. Operative morbidity for UC and CD was 33 and 17 %, respectively. Despite the less favourable operative outcomes following surgery management of UC-related CRC, overall 5-year survival was significantly better in the UC group compared to the CD group (41 vs. 29 %; p = 0.04) reflecting the difference in stage at presentation between the two groups. CONCLUSIONS: Patients who undergo surgery for UC-related CRC have less favourable short-term outcomes but present at a less advanced stage and have a more favourable long-term prognosis than similar patients with CRC and CD. |
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Authors:
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D O Kavanagh; M C Carter; D Keegan; G Doherty; M J Smith; J M P Hyland; H Mulcahy; K Sheahan; P R O' Connell; D P O' Donoghue; D C Winter |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-14 |
Journal Detail:
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Title: Techniques in coloproctology Volume: - ISSN: 1128-045X ISO Abbreviation: Tech Coloproctol Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9613614 Medline TA: Tech Coloproctol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center for Colorectal Disease, St. Vincent's University Hospital, Dublin, Ireland, dara_kav@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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