| Management and clinical outcomes of pregnant patients with invasive cervical cancer. | |
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MedLine Citation:
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PMID: 15668263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The objective of this study was to evaluate the clinical outcomes and to discuss the management of women presenting with an invasive cervical cancer during pregnancy. PATIENTS AND METHODS: We retrospectively reviewed patients treated for an invasive cervical cancer diagnosed during pregnancy between 1985 and 2000 in our institution. RESULTS: Twenty-one pregnant patients among a total of 487 women were treated. Thirteen, five, two and one, respectively, were diagnosed during the first, second and third pregnancy trimester and post-partum. The FIGO stage was IB in 15 cases, IIB in five cases and IVA in one case. Mean follow-up was 64 months (range 2-165). Overall and disease-free survival at 5 years were 82% and 79%, respectively. All five patients diagnosed in the second trimester were alive. Two of the 13 patients and one of the two patients diagnosed during the first trimester and the third trimester, respectively, died of their disease. No difference was observed between the nine patients whose treatment was delayed or not. CONCLUSIONS: Invasive cervical cancer during pregnancy is rare but is a dilemma for women and their physicians. The present study and review of the literature suggest that pregnancy does not seem to influence the prognosis of cervical cancer. Delayed treatment could be proposed to selected patients diagnosed at the end of the second trimester or at the beginning of the third trimester, with a small tumor (<2 cm) and negative nodes, after a multidisciplinary approach. |
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Authors:
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N Germann; C Haie-Meder; P Morice; C Lhomme; P Duvillard; K Hacene; A Gerbaulet |
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Publication Detail:
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Type: Journal Article Date: 2005-01-24 |
Journal Detail:
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Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 16 ISSN: 0923-7534 ISO Abbreviation: Ann. Oncol. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-21 Completed Date: 2005-08-04 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: England |
Other Details:
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Languages: eng Pagination: 397-402 Citation Subset: IM |
Affiliation:
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Department of radiothérapie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94 805 Villejuif, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Disease-Free Survival Female Humans Neoplasm Invasiveness* Patient Selection Pregnancy Pregnancy Complications, Neoplastic / pathology*, therapy* Pregnancy Outcome Pregnancy Trimesters Prognosis Retrospective Studies Time Factors Uterine Cervical Neoplasms / pathology*, therapy* |
| Comments/Corrections | |
Comment In:
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Ann Oncol. 2005 Mar;16(3):341-3
[PMID:
15722461
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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