| Management of cirrhotic ascites: physiological basis of diuretic action. | |
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MedLine Citation:
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PMID: 16378879 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Ascites is a significant complication of cirrhosis that occurs in approximately 50% of patients. The mortality rate is high in patients with cirrhosis and ascites. Conventional interventions rest with dietary sodium restriction, diuretic use, large-volume paracentesis, peritoneovenous shunts and transjugular intrahepatic portosystemic shunts. The mainstay of therapy, however, is the judicious use of diuretics. This article reviews the physiological basis of diuretic use in patients with cirrhosis and ascites, as well as recent concepts on the pathogenesis of ascites formation. Through a better understanding of the pathophysiology of ascites formation and the mechanism of action of diuretics, improved extracellular fluid balance can be achieved in these patients. |
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Authors:
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Mitchell H Rosner; Rohit Gupta; David Ellison; Mark D Okusa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of internal medicine Volume: 17 ISSN: 0953-6205 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-27 Completed Date: 2006-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 8-19 Citation Subset: - |
Affiliation:
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Division of Nephrology, University of Virginia School of Medicine, Box 133 Health Science Center, Charlottesville, VA 22908-0001, USA. mhr9r@virginia.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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