Document Detail

Management of cholestasis in infants with very low birth weight.
MedLine Citation:
PMID:  10807232     Owner:  NLM     Status:  MEDLINE    
Infants with very low birth weight (VLBW) are at increased risk of cholestasis when compared with older infants and children. Factors associated with this increased risk of cholestasis include immaturity of the biliary excretory system, a diminished immune response to sepsis, an increased incidence of necrotizing enterocolitis and short bowel syndrome, as well as an increased exposure to parenteral nutrition (PN). The current literature on cholestasis in VLBW infants and the factors that mediate the initiation and progression of cholestatic liver damage is reviewed. A protocol for managing infants with cholestatic jaundice is presented, and a case report is included that shows use of the protocol to normalize the bilirubin in a VLBW infant with severe cholestatic jaundice.
E Owings; K Georgeson
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Seminars in pediatric surgery     Volume:  9     ISSN:  1055-8586     ISO Abbreviation:  Semin. Pediatr. Surg.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-29     Completed Date:  2000-08-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9216162     Medline TA:  Semin Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM    
The Children's Hospital of Alabama, Birmingham 35233, USA.
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MeSH Terms
Bilirubin / blood
Cholestasis / blood,  physiopathology,  therapy*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / physiopathology,  therapy*
Infant, Very Low Birth Weight*
Parenteral Nutrition
Reg. No./Substance:

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