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Management of cerebral perfusion pressure.
MedLine Citation:
PMID:  16088656     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The management of cerebral perfusion pressure is among the most controversial treatment issues. Cerebral perfusion pressure (CPP) is normally expressed as the difference between mean arterial blood pressure and intracranial pressure and has two important physiological roles in the patient with severe head injury. First, CPP represents the pressure gradient acting across the cerebrovascular bed and hence is an important factor in the regulation of cerebral blood flow. Second, CPP contributes to the hydrostatic pressure within the intracerebral vessels, and therefore is one of the factors that determines edema formation in the injured brain. The border between adequate and inadequate CPP should be assessed individually and continuously, as it may fluctuate in time. The treatment plan that includes rapid identification of intracranial hemorrhage, rapid evacuation of extra-axial blood, treatment of intracranial hypertension, and promotion of cerebral and systemic perfusion is likely to provide the best outcome for all patients.
R Hlatky; Y Furuya; A B Valadka; C S Robertson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in respiratory and critical care medicine     Volume:  22     ISSN:  1069-3424     ISO Abbreviation:  Semin Respir Crit Care Med     Publication Date:  2001  
Date Detail:
Created Date:  2005-08-09     Completed Date:  2005-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431858     Medline TA:  Semin Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-12     Citation Subset:  -    
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA.
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