Document Detail

Management of blood pressure instability in severe tetanus: the use of clonidine.
MedLine Citation:
PMID:  9310809     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effectiveness of clonidine in the management of unstable blood pressure in severe tetanus. DESIGN: Patients with severe tetanus and blood pressure instability were treated with clonidine and the results were compared with those of other patients with severe tetanus who were not treated with clonidine. SETTING: Intensive care unit of the Chest Hospital of Athens. PATIENTS: We studied 27 patients with severe tetanus and autonomic dysfunction. INTERVENTIONS: Patients were managed according to a protocol. MEASUREMENTS AND RESULTS: Clonidine was administered until blood pressure stability was the fully restored and the dose was then gradually reduced. Five patients from the nonclonidine group and 2 from the clonidine group died. CONCLUSIONS: These results suggest that clonidine is effective in the treatment of blood pressure instability in severe tetanus.
L Gregorakos; E Kerezoudi; G Dimopoulos; T Thomaides
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Intensive care medicine     Volume:  23     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-12-04     Completed Date:  1997-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  893-5     Citation Subset:  IM    
Department of Respiratory Insufficiency, Chest Hospital of Athens, Greece.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology,  therapeutic use*
Aged, 80 and over
Autonomic Nervous System Diseases / drug therapy*,  etiology
Blood Pressure / drug effects*
Clonidine / pharmacology,  therapeutic use*
Greece / epidemiology
Middle Aged
Statistics, Nonparametric
Survival Rate
Tetanus / complications,  drug therapy*,  mortality
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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