Document Detail

Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine.
MedLine Citation:
PMID:  2094230     Owner:  NLM     Status:  MEDLINE    
The treatment of severe tetanus with autonomic dysfunction is discussed, with emphasis on the use of magnesium sulphate. An exemplary case is reported, describing the inadequate response to magnesium, but the previously unreported and successful use of clonidine to control sympathetic overactivity. The properties of clonidine are reviewed. Clonidine is felt to be a logical and appropriate drug for the treatment of autonomic dysfunction in severe tetanus.
D N Sutton; M R Tremlett; T E Woodcock; M S Nielsen
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Intensive care medicine     Volume:  16     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1990  
Date Detail:
Created Date:  1990-06-07     Completed Date:  1990-06-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  IM    
Shackleton Department of Anaesthetics, Southampton General Hospital, UK.
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MeSH Terms
Autonomic Nervous System Diseases / blood,  drug therapy*,  etiology
Catecholamines / blood
Clonidine / administration & dosage,  pharmacology,  therapeutic use*
Infusions, Intravenous
Magnesium Sulfate / administration & dosage,  pharmacology,  therapeutic use*
Middle Aged
Tetanus / complications*,  physiopathology
Reg. No./Substance:
0/Catecholamines; 4205-90-7/Clonidine; 7487-88-9/Magnesium Sulfate
Comment In:
Intensive Care Med. 1990;16(8):520   [PMID:  2286735 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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