Document Detail


Management of atrial fibrillation.
MedLine Citation:
PMID:  20875341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atrial fibrillation (AF) is the most common heart rhythm problem and a leading cause of morbidity and mortality. Serious complications associated with this disorder include cardioembolic stroke, heart failure, and death. The worldwide prevalence of AF is rapidly increasing owing to aging of the population. Abnormal impulse formation in the pulmonary veins is known to trigger paroxysmal AF and radiofrequency isolation of these veins is recommended in drug-refractory AF. Active pharmacological research is directed towards selectively targeting the culprit venous cells. Persistent AF is more likely to be an atrial disease. Intrinsic and extrinsic stressors are believed to cause electrostructural alterations in the atrial tissue leading to profibrillatory state. Further research will elucidate the role of stressors and help develop biomarkers to guide early management of AF. An ideal therapy for AF aims at prevention of onset and progression of AF and reduction of AF-related symptoms, hospitalization, stroke, and mortality.
Authors:
Ashok J Shah; Amir S Jadidi; Shinsuke Miyazaki; Olivier Xhaet; Nick Linton; Daniel Scherr; Xingpeng Liu; Andrei Forclaz; Isabelle Nault; Lena Rivard; Nicolas Derval; Frederic Sacher; Pierre Bordachar; Philippe Ritter; Meleze Hocini; Pierre Jais; Michel Haissaguerre
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Discovery medicine     Volume:  10     ISSN:  1944-7930     ISO Abbreviation:  Discov Med     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101250006     Medline TA:  Discov Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  IM    
Affiliation:
Hôpital Cardiologique du Haut-Lévêque and the Université Bordeaux II, Bordeaux, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents / therapeutic use
Atrial Fibrillation / drug therapy,  epidemiology*,  physiopathology,  therapy
Catheter Ablation
Heart Atria / drug effects,  surgery
Humans
Pulmonary Veins / drug effects,  surgery
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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