| Management of aplastic anemia: the role of systematic reviews and meta-analyses. | |
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MedLine Citation:
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PMID: 21150187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aplastic anemia is a rare bone marrow failure disorder. Allogeneic hematopoietic cell transplantation (alloHCT) and immunosuppressive therapy (IST) are the main therapeutic modalities currently used to treat patients with aplastic anemia. Systematic reviews and meta-analyses of randomized controlled trials (RCTs) are regarded as the highest level of evidence and as such aid practitioners in solving clinical questions. The objective of this review is to assess the base of evidence for the common practice and the current guidelines for the management of aplastic anemia. It focuses on data obtained from systematic reviews and meta-analyses of RCTs conducted in this field. Specifically, it focuses on four major therapeutic questions: the roles of alloHCT, IST, hematopoietic growth factors and supportive care. |
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Authors:
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Anat Gafter-Gvili; Ron Ram; Pia Raanani; Ofer Shpilberg |
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Publication Detail:
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Type: Journal Article Date: 2010-12-08 |
Journal Detail:
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Title: Acta haematologica Volume: 125 ISSN: 1421-9662 ISO Abbreviation: Acta Haematol. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 47-54 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Institute of Hematology, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Tel Aviv University, Israel. anatga2@clalit.org.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Aplastic
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drug therapy,
therapy* Hematopoietic Cell Growth Factors / therapeutic use Hematopoietic Stem Cell Transplantation / methods Humans Immunosuppressive Agents / therapeutic use Meta-Analysis as Topic Review Literature as Topic Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Hematopoietic Cell Growth Factors; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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