Document Detail

Management of anti-Jka alloimmunization.
MedLine Citation:
PMID:  19370894     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether prenatal management using guidelines established for anti-D is applicable to anti-Jka. STUDY DESIGN: A computerized database containing the records of all alloimmunized pregnancies at The Ohio State University Medical Center with due dates from 1959 to 2008 was used to identify pregnancies affected only by anti-Jka. Only cases with evidence that the newborn was Jka antigen positive were included. RESULTS: Twenty affected pregnancies met inclusion criteria. Of those, 16 pregnancies required monitoring with serum titers only and 4 were followed with more diagnostic tests as recommended during that time period. One pregnancy with the highest titer of 32 and elevated middle cerebral artery peak systolic velocity (MCA PSV) required 4 intrauterine transfusions for fetal anemia. Another pregnancy with a titer of 32 had an infant who required phototherapy for hemolytic disease of the fetus/newborn (HDFN), with a hemoglobin value of 15.9 g/dL. None of the other 18 infants required any therapy for HDFN. CONCLUSION: Our case series identified severe disease in 1 of 20 pregnancies from anti-Jka using maternal antibody titer and MCA PSV. Criteria used for monitoring RhD alloimmunization were effective in detecting severe HDFN resulting from to anti-Jka.
Albert Franco; Karen Rossi; Dave Krugh; Richard O'Shaughnessy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  54     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.
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MeSH Terms
Anemia / diagnosis,  therapy*
Blood Flow Velocity
Blood Group Antigens / immunology*
Blood Group Incompatibility / therapy*
Blood Transfusion, Intrauterine*
Erythroblastosis, Fetal / diagnosis,  immunology,  therapy*
Fetal Blood / immunology
Fetal Diseases / diagnosis,  therapy
Hemoglobins / analysis
Infant, Newborn
Isoantibodies / analysis*
Middle Cerebral Artery / physiology
Prenatal Care
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Blood Group Antigens; 0/Hemoglobins; 0/Isoantibodies

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