Document Detail

Management of acute myocardial infarction: evaluating the past, practicing in the present, elaborating the future.
MedLine Citation:
PMID:  8694005     Owner:  NLM     Status:  MEDLINE    
The management of acute myocardial infarction initially focused on treatment and/or prevention of complications. In the prethrombolytic era, therapeutic regimens mainly comprised the use of antianginal and antiarrhythmic drugs. The development of semi-invasive hemodynamically guided treatment concepts led to remarkable improvement in clinical outcome. After the introduction of the "wave-front phenomenon," multiple pharmacologic treatment strategies were developed with the goal of infarct size reduction. The use of thrombolytic agents reduced infarct size and improved prognosis of patients with acute myocardial infarction. Acute angioplastic intervention was introduced in specialized centers to achieve rapid restoration of coronary blood flow. The protection of the myocardium from reperfusion injury, however, remains an unresolved issue. Intravenous magnesium administration in conjunction with new and better recanalization techniques could therefore be a promising therapy strategy in patients with acute myocardial infarction.
D Glogar; P Yang; G Steurer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American heart journal     Volume:  132     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-08-29     Completed Date:  1996-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  465-70; discussion 496-502     Citation Subset:  AIM; IM    
Department of Cardiology, University of Vienna Medical School, Austria.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Calcium Channel Blockers / therapeutic use
Clinical Trials as Topic
Fibrinolytic Agents / therapeutic use
Magnesium Sulfate / therapeutic use
Myocardial Infarction / drug therapy*,  mortality
Streptokinase / therapeutic use
Thrombolytic Therapy*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Fibrinolytic Agents; 7487-88-9/Magnesium Sulfate; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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