| Management of acute haemarthrosis in haemophilia A without inhibitors: literature review, European survey and recommendations. | |
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MedLine Citation:
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PMID: 21323794 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Summary. Acute haemarthrosis is a frequent type of bleeding in individuals with haemophilia. Delayed and/or inadequate treatment can trigger a series of pathological changes within the joint, leading to a painful and disabling arthropathy. The early management of intra-articular bleeding has the potential to prevent chronic joint disease and may include a combination of factor replacement, rest, ice, rehabilitation and, in certain cases, joint aspiration. Little data are, however, available regarding the optimal management of acute haemarthrosis, especially with respect to replacement therapy and the use of adjunctive therapies (aspiration, avoidance of weight bearing and immobilization, as well as the use of anti-inflammatory medication and embolization). To provide more insight into the management of acute haemarthrosis in patients with haemophilia, a literature review was conducted. Concomitantly, current management was surveyed in 26 European haemophilia comprehensive care centres representing 15 different countries. The review highlights the need for future robust studies to better define the appropriate replacement therapy and the role of adjunctive therapies such as aspiration. The survey reveals much heterogeneity in the management of acute haemarthrosis across the EU. Within the constraints discussed, treatment recommendations are presented that reflect the literature, current practice and the clinical experience of the European Haemophilia Therapy Standardisation Board (EHTSB). |
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Authors:
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C Hermans; P DE Moerloose; K Fischer; K Holstein; R Klamroth; T Lambert; G Lavigne-Lissalde; R Perez; M Richards; G Dolan; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-15 |
Journal Detail:
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Title: Haemophilia : the official journal of the World Federation of Hemophilia Volume: - ISSN: 1365-2516 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9442916 Medline TA: Haemophilia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Haemostasis-Thrombosis Unit, Division of Haematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium Unité d'Hémostase, Hôpitaux Universitaires de Genève, Geneva, Switzerland Van Creveld Clinic, Utrecht, Netherlands Onkologisches Zentrum, II. Medizinische Klinik und Poliklinik, Universitätsklinik, Hamburg, Germany Vivantes - Klinikum in Friedrichhain Klinik fuer Innere Medizin Haemophiliezentrum, Berlin, Germany CHU Kremlin - Bicètre, Paris, France Laboratoire d'Hématologie, Groupe Hospitalo-Universitaire Caremeau, Nîmes, France Hospital Virgen del Rocio, Seville, Spain Paediatric Haematology Department, Children's Day Hospital, St. James University Hospital, Leeds, UK Queen's Medical Centre, University Hospital, Nottingham, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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