Document Detail

Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline.
MedLine Citation:
PMID:  22869843     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim was to update the guidelines for the management of thyroid dysfunction during pregnancy and postpartum published previously in 2007. A summary of changes between the 2007 and 2012 version is identified in the Supplemental Data (published on The Endocrine Society's Journals Online web site at
EVIDENCE: This evidence-based guideline was developed according to the U.S. Preventive Service Task Force, grading items level A, B, C, D, or I, on the basis of the strength of evidence and magnitude of net benefit (benefits minus harms) as well as the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence.
CONSENSUS PROCESS: The guideline was developed through a series of e-mails, conference calls, and one face-to-face meeting. An initial draft was prepared by the Task Force, with the help of a medical writer, and reviewed and commented on by members of The Endocrine Society, Asia and Oceania Thyroid Association, and the Latin American Thyroid Society. A second draft was reviewed and approved by The Endocrine Society Council. At each stage of review, the Task Force received written comments and incorporated substantive changes.
CONCLUSIONS: Practice guidelines are presented for diagnosis and treatment of patients with thyroid-related medical issues just before and during pregnancy and in the postpartum interval. These include evidence-based approaches to assessing the cause of the condition, treating it, and managing hypothyroidism, hyperthyroidism, gestational hyperthyroidism, thyroid autoimmunity, thyroid tumors, iodine nutrition, postpartum thyroiditis, and screening for thyroid disease. Indications and side effects of therapeutic agents used in treatment are also presented.
Leslie De Groot; Marcos Abalovich; Erik K Alexander; Nobuyuki Amino; Linda Barbour; Rhoda H Cobin; Creswell J Eastman; John H Lazarus; Dominique Luton; Susan J Mandel; Jorge Mestman; Joanne Rovet; Scott Sullivan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  97     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-07     Completed Date:  2012-10-24     Revised Date:  2012-12-12    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2543-65     Citation Subset:  AIM; IM    
University of Rhode Island, Providence, Rhode Island 02881, USA.
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MeSH Terms
Evidence-Based Medicine
Hyperthyroidism / therapy
Postpartum Period*
Practice Guidelines as Topic*
Pregnancy Complications / therapy*
Puerperal Disorders / therapy*
Thyroid Diseases / therapy*
Thyroiditis / therapy
Comment In:
Nat Rev Endocrinol. 2012 Nov;8(11):624   [PMID:  22926097 ]
J Clin Endocrinol Metab. 2012 Aug;97(8):2632-5   [PMID:  22869849 ]

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