Document Detail


Management of HCC.
MedLine Citation:
PMID:  22300468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal neoplasia, the management of which has significantly improved during the last few years. A better knowledge of the natural history of the tumor and the development of staging systems that stratify patients according to the characteristics of the tumor, the liver disease, and the performance status, such as the BCLC (Barcelona Clinic Liver Cancer) system, have led to a better prediction of prognosis and to a most appropriate treatment approach. Today curative therapies (resection, transplantation, ablation) can improve survival in patients diagnosed at an early HCC stage and offer a potential long-term cure. Patients with intermediate stage HCC benefit from chemoembolization and those diagnosed at advanced stage benefit from sorafenib, a multikinase inhibitor with antiangiogenic and antiproliferative effects. In this article we review the current management in HCC and the new advances in this field.
Authors:
Carlos Rodríguez de Lope; Silvia Tremosini; Alejandro Forner; María Reig; Jordi Bruix
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of hepatology     Volume:  56 Suppl 1     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-06-08     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S75-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Affiliation:
Barcelona Clinic Liver Cancer Group, Liver Unit, ICMDM, Hospital Clínic, IDIBAPS, University of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Hepatocellular / diagnosis,  pathology*,  therapy*
Catheter Ablation
Chemoembolization, Therapeutic
Early Detection of Cancer*
Hepatectomy
Humans
Liver Neoplasms / diagnosis,  pathology*,  therapy*
Liver Transplantation
Molecular Targeted Therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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