| Management of exercise-induced glycemic imbalances in type 1 diabetes. | |
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MedLine Citation:
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PMID: 21682691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regular moderate-intensity exercise is strongly recommended for its beneficial effects in all people. In patients with type 1 diabetes, however, the exercise-associated glycemic imbalances remain an unresolved clinical challenge. Current guidelines require an in-depth understanding of the glycemic responses to exercise and each patient has to discover, by trial-and-error, his/her own strategy, several attempts being usually required to gain sufficient experience. Consequently, fear of hypoglycemia remains the strongest barrier to physical activity. This paper explores the potential strategies that may be employed to minimize the risk of exercise related glycemic imbalances. Moreover, a newly developed algorithm (ECRES, Exercise Carbohydrate Requirement Estimating Software) is described, which estimates on a patient- and situation-specific basis the glucose supplement required by the patient to maintain safe blood glucose levels. The algorithm was tested on 27 patients who performed three 1-hr constant intensity walks (each starting at a different time interval following insulin injection). Results showed that in 70.4% of the trials, independent of the time of day, the algorithm provided a satisfactory estimate of the carbohydrates needed by patients to complete the exercise with a glucose level within safe thresholds (i.e. 3.9 - 10 mmol·L-1). Despite the algorithm requires further experimental testing to be applied by the majority of patients, these results indicate its potential usefulness as a tool for preventing immediate exercise-induced glycemic imbalances (i.e. during exercise) in type 1 diabetic patients, in particular for spontaneous activities not planned in advance, thus allowing all insulin-dependent patients to safely enjoy the benefits of exercise. |
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Authors:
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Maria P Francescato; Sergio Carrato |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current diabetes reviews Volume: 7 ISSN: 1875-6417 ISO Abbreviation: Curr Diabetes Rev Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-12 Completed Date: 2011-11-21 Revised Date: 2012-04-23 |
Medline Journal Info:
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Nlm Unique ID: 101253260 Medline TA: Curr Diabetes Rev Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 253-63 Citation Subset: IM |
Affiliation:
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Department of Medical and Biological Sciences, School of Medicine, University of Udine, Udine, Italy. maria.francescato@uniud.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 1
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blood,
complications*,
metabolism,
therapy* Exercise / physiology* Humans Hypoglycemia / blood, etiology*, prevention & control, therapy* Insulin / blood Models, Biological Motor Activity / physiology |
| Chemical | |
Reg. No./Substance:
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0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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