Document Detail

Management of Eisenmenger syndrome in pregnancy with sildenafil and L-arginine.
MedLine Citation:
PMID:  15121629     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Eisenmenger syndrome in pregnancy may be a life-threatening disease despite recent additions to the treatment options. CASE: We present a woman with severe pulmonary hypertension due to Eisenmenger syndrome treated during pregnancy and delivery and postpartum with L-arginine and sildenafil to enhance the nitric oxide pathway. This combination was associated with significant improvement in the mother's clinical and hemodynamic condition and fetal well-being. CONCLUSION: The concomitant use of sildenafil and L-arginine for the management of pulmonary hypertension in pregnancy, combined with multidisciplinary care, permitted a good outcome for the mother and her infant.
Héctor J Lacassie; Alfredo M Germain; Gloria Valdés; M Soledad Fernández; Francisco Allamand; Héctor López
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  103     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-06-04     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1118-20     Citation Subset:  AIM; IM    
Pontificia Universidad Católica de Chile, Santiago, Chile.
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MeSH Terms
3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors*
Arginine / therapeutic use*
Drug Therapy, Combination
Eisenmenger Complex / drug therapy*
Hypertension, Pulmonary / drug therapy*,  etiology
Patient Care Team
Phosphodiesterase Inhibitors / therapeutic use*
Piperazines / therapeutic use*
Pregnancy Complications, Cardiovascular / drug therapy*
Pregnancy Outcome
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil; 74-79-3/Arginine; EC',5'-Cyclic-GMP Phosphodiesterases

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