| Management of AIDS-related Kaposi sarcoma: advances in target discovery and treatment. | |
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MedLine Citation:
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PMID: 15199854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kaposi sarcoma (KS) is the most common tumor arising in HIV-infected patients and is considered an AIDS-defining illness by CDC guidelines. Recent advances in the elucidation of the pathogenesis of KS continue to uncover potential targets for therapies. Such targets include the KS herpesvirus/human herpesvirus 8 and the processes of angiogenesis and cellular differentiation. Five agents are currently approved by the FDA for the treatment o KS: alitretinoin gel for topical administration and liposomal daunorubicin, liposomal doxorubicin, paclitaxel, and interferon-alpha for systemic administration. Many more agents, particularly angiogenesis inhibitors and other pathogenesis-targeted therapies, are in clinical development. With increasing recognition that effective antiretroviral regimens are associated with both a decreased proportion of new AIDS-defining KS cases and a regression in the size and number of existing KS lesions, most, if not all, patients with KS should be advised to take antiretroviral drugs that will maximally decrease HIV-1 RNA levels. |
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Authors:
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Bruce J Dezube; Liron Pantanowitz; David M Aboulafia |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The AIDS reader Volume: 14 ISSN: 1053-0894 ISO Abbreviation: AIDS Read Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-06-01 Completed Date: 2004-06-18 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9206753 Medline TA: AIDS Read Country: United States |
Other Details:
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Languages: eng Pagination: 236-8, 243-4, 251-3 Citation Subset: X |
Affiliation:
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AIDS Malignancy Research and Treatment Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Anti-HIV Agents / therapeutic use Antineoplastic Agents / therapeutic use Diagnosis, Differential Drugs, Investigational Humans Neoplasm Staging Sarcoma, Kaposi / drug therapy*, etiology, pathology* Skin Neoplasms / drug therapy*, etiology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Antineoplastic Agents; 0/Drugs, Investigational |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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