Document Detail

Mammographically Detectable Breast Arterial Calcification And Atherosclerosis: A Review.
MedLine Citation:
PMID:  23584424     Owner:  NLM     Status:  Publisher    
Breast artery calcification (BAC), observed as an incidental finding on screening mammograms, represents degenerative calcific changes occurring in the mammary arteries, increasing with age. The aim of this review is to discuss relevant literature examining relationship between BAC and atherosclerosis. After a thorough literature search in OVID and PUBMED, 199 studies were identified, of which 25 were relevant to our review. Data was abstracted from each study and statistical analysis was done including calculation of odds ratios and construction of forest plots. A total of 35,542 patients were enrolled across 25 studies looking at an association between BAC and coronary artery disease (CAD), cardiovascular disease (CVD), stroke, cerebral artery disease, carotid and peripheral artery diseases and coronary artery calcification. A majority of the studies showed a statistically significant relationship between BAC and the presence of CAD and CVD, as well as associated mortality. Sensitivity of BAC in predicting CV events was low, specificity was high. BAC was predictive of incident and prevalent stroke but not stroke mortality. Similarly, BAC was predictive of cerebral, carotid and peripheral artery disease. Thus, the role of BAC as a surrogate marker of coronary and systemic atherosclerosis is currently uncertain. Its role may be further elucidated by more large scale prospective studies and clinical experience.
Neeraj Shah; Vinod Chainani; Patrice Delafontaine; Abir Abdo; James Lafferty; Nidal Abi Rafeh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-11
Journal Detail:
Title:  Cardiology in review     Volume:  -     ISSN:  1538-4683     ISO Abbreviation:  Cardiol Rev     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Medicine, Staten Island University Hospital, Staten Island, New York1, Divisions of Cardiology, Staten Island University Hospital2 and Tulane University Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana3 and the Section of Geriatric Medicine, Louisiana State University School of Medicine, New Orleans, Louisiana4.
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