| Mammographic appearance following accelerated partial breast irradiation by using MammoSite brachytherapy. | |
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MedLine Citation:
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PMID: 20332376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe a single institution's experience with mammographic appearance in low-risk patients with early stage breast cancer who have received accelerated partial breast irradiation (APBI) by using MammoSite balloon brachytherapy. MATERIALS AND METHODS: This study was approved by an institutional review board and was conducted under strict adherence to the Privacy Rule of HIPAA. This was a retrospective review of patients who underwent MammoSite brachytherapy from October 2003 to March 2007. Informed consent for participation in the research project was waived by the institutional review board. Posttherapy mammograms were categorized as showing mild, moderate, or severe distortion and were correlated with patient complaints and complications. RESULTS: Twenty-two women were included in the study, and 93 mammograms were obtained during a median follow-up period of 46 months (range, 22-58 months). Median age was 61 years (range, 47-81 years). One patient developed severe distortion after APBI, while two patients developed only mild distortion throughout follow-up. Eleven (79%) of 14 patients developed moderate distortion, with a median peak in distortion occurring at 21 months. Four (18%) patients developed fat necrosis, two (9%) developed seromas, and two (9%) developed both fat necrosis and seromas. None of the patients required biopsy, and none had an ipsilateral breast recurrence. One patient died of metastatic disease with no evidence of local recurrence. CONCLUSION: Patients treated with MammoSite APBI developed peak distortion 21 months following therapy, which may be sooner than distortion following conventional whole breast radiation. |
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Authors:
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Haitham M Ahmed; Pamela J Dipiro; Phillip M Devlin; My-Linh Nguyen; Jennifer R Bellon |
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Publication Detail:
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Type: Journal Article Date: 2010-03-23 |
Journal Detail:
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Title: Radiology Volume: 255 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 362-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiation Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA. haitham.m.ahmed@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Brachytherapy / instrumentation, methods* Breast Neoplasms / pathology, radiography, radiotherapy* Female Humans Mammography* Middle Aged Radiation Injuries / radiography* Retrospective Studies Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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