Document Detail

Mammary immunity in mothers of infants with respiratory syncytial virus infection.
MedLine Citation:
PMID:  3625176     Owner:  NLM     Status:  MEDLINE    
Seven of 230 breast fed infants followed prospectively from birth through their first winter contracted RS virus infections. The colostral from five of the mothers of these infants contained antiviral IgA antibodies. In each case antibody levels were above the mean for a group of 36 mothers whose infants were age matched to infected infants but for whom there was no evidence of RS virus infection in their first winter. Four colostral samples from mothers of infected infants also contained antiviral IgG antibody. Colostral lymphocyte reactivity to RS virus antigen was tested in three mothers of infected infants and two showed significant proliferation. There was, therefore, no evidence that mothers of infected infants lacked mammary immunity to the virus. Maternal mammary IgA and IgG responses following diagnosis of RS virus infection in the infant were followed for the seven cases identified prospectively and for a further 23 infants admitted to hospital with RS virus infections of varying severity. There was no evidence that the mothers of more severely affected infants were deficient in IgA or IgG milk antibody.
N Nandapalan; C Taylor; R Scott; G L Toms
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  22     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-10-02     Completed Date:  1987-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-87     Citation Subset:  IM    
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MeSH Terms
Antibodies, Viral / analysis*
Antigens, Viral / immunology
Breast Feeding
Colostrum / immunology*
Immunity, Maternally-Acquired
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Infant, Newborn
Lymphocyte Activation
Milk, Human / immunology*
Prospective Studies
Respiratory Syncytial Viruses / immunology*
Respirovirus Infections / immunology*
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/Immunoglobulin A; 0/Immunoglobulin G

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