| Mammary gland function and development: effect of zinc deficiency in rat. | |
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MedLine Citation:
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PMID: 7356013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of dietary zinc deficiency during late pregnancy and lactation on the rat mammary gland was investigated by feeding female rats either a zinc-deficient diet (0.4 ppm Zn) or a zinc-sufficient diet (100 ppm Zn) ad libitum or restricted in amount. Zinc deficiency from day 0 of lactation specifically reduced the total RNA content of lactating mammary glands on day 14, but had no effect beyond that of food restriction on their total DNA content, Both RNA and DNA content of the mammary gland were decreased by reduced food intake. Zinc deficiency from day 14 of pregnancy to day 2 of lactation severely impaired parturition and prevented the normal rise in mammary gland RNA seen during lactogenesis in control animals. A shorter deficiency period, from day 18 of gestation, had no effect on mammary gland nucleic acids other than that due to inanition. |
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Authors:
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P B Mutch; L S Hurley |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 238 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-04-25 Completed Date: 1980-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E26-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast / physiopathology* DNA / metabolism Female Lactation* Milk / metabolism* Pregnancy RNA / metabolism Rats Zinc / deficiency*, metabolism |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; 7440-66-6/Zinc; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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