Document Detail


Mammary gland development is delayed in mice deficient for aminopeptidase N.
MedLine Citation:
PMID:  22983824     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Development of the mammary gland requires the coordinated action of proteolytic enzymes during two phases of remodelling. Firstly, new ducts and side-branches thereof need to be established during pregnancy to generate an extensive ductal tree allowing the secretion and transport of milk. A second wave of remodelling occurs during mammary involution after weaning. We have analysed the role of the cell surface protease aminopeptidase N (Anpep, APN, CD13) during these processes using Anpep deficient and Anpep over-expressing mice. We find that APN deficiency significantly delays mammary gland morphogenesis during gestation. The defect is characterised by a reduction in alveolar buds and duct branching at mid-pregnancy. Conversely over-expression of Anpep leads to accelerated ductal development. This indicates that Anpep plays a critical role in the proteolytic remodelling of mammary tissue during adult mammary development.
Authors:
Andreas F Kolb; David Sorrell; Caroline Lassnig; Simon Lillico; Ailsa Carlisle; Claire Neil; Claire Robinson; Mathias Müller; C Bruce A Whitelaw
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-15
Journal Detail:
Title:  Transgenic research     Volume:  -     ISSN:  1573-9368     ISO Abbreviation:  Transgenic Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209120     Medline TA:  Transgenic Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Metabolic Health Division, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen, AB21 9SB, Scotland, UK, A.kolb@abdn.ac.uk.
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