Document Detail


Mammary arteriovenous differences of glucose, insulin, prolactin and IGF-I in lactating sows under different protein intake levels.
MedLine Citation:
PMID:  17118618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammary uptake of nutrients is dependent on their availability in the circulation but the role of hormones in that process is not known. Arteriovenous differences (AVD) of glucose and key hormones across the mammary glands were therefore determined in sows fed varying levels of protein. Sixteen lactating sows (four/dietary treatment) were fed a 7.8, 13.0, 18.2 or 23.5% crude protein (CP) isocaloric diet throughout lactation and their litters were standardized to 11 pigs within 48 h of birth. The anterior main mammary vein and a carotid artery were cannulated on day 4+/-1 of lactation and blood samples were collected every 30 min over 6h on days 10, 14, 18 and 22 of lactation to measure glucose, insulin, IGF-I, and prolactin (PRL) concentrations. Amino acid data from these sows were previously published and used here to determine residual correlations. Dietary treatments had no effect on any of the insulin or PRL variables measured (P>0.1) and, on day 18 only, IGF-I AVD was greater (P=0.05) for sows on the 23.5% compared to the 18.2% diet. On days 18 and 22, sows fed the 13% CP diet had greater arterial, venous and AVD glucose concentrations than sows fed other diets (P<0.05). Total arterial amino acid concentrations were correlated to arterial insulin (P<0.001) and PRL (P<0.05) concentrations, but not to those of IGF-I (P>0.1). Mammary AVD for total (P<0.001) and essential amino acids (P<0.05) were correlated to arterial concentrations of insulin, but not to those of IGF-I (P>0.1) or PRL (P>0.1). Mammary AVD of both total (P<0.01) and essential (P<0.05) amino acids were also correlated to mammary PRL AVD. In conclusion, dietary protein level did not affect mammary AVD and circulating lactogenic hormone concentrations. Yet, amino acid utilization by the sow mammary gland seems to be regulated via both circulating insulin concentrations and PRL binding to and uptake by porcine mammary cells.
Authors:
Chantal Farmer; Xinfu Guan; Nathalie L Trottier
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Publication Detail:
Type:  Journal Article     Date:  2006-11-13
Journal Detail:
Title:  Domestic animal endocrinology     Volume:  34     ISSN:  0739-7240     ISO Abbreviation:  Domest. Anim. Endocrinol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505191     Medline TA:  Domest Anim Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-62     Citation Subset:  IM    
Affiliation:
Agriculture and Agri-Food Canada, Dairy and Swine R&D Centre, P.O. Box 90, STN Lennoxville, Sherbrooke, Que. J1M 1Z3, Canada. farmerc@agr.gc.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Carotid Arteries / physiology
Dietary Proteins / administration & dosage*,  metabolism
Female
Insulin / blood*
Insulin-Like Growth Factor I / metabolism*
Lactation
Mammary Glands, Animal / blood supply*,  metabolism
Prolactin / metabolism*
Random Allocation
Swine / metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Proteins; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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