| Mammary Gland Morphological and Gene Expression Changes Underlying Pregnancy Protection of Breast Cancer Tumorigenesis. | |
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MedLine Citation:
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PMID: 22085904 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A full-term pregnancy early in life reduces lifetime risk of developing breast cancer and the effect can be mimicked in rodents by full term pregnancy and short-term treatment with exogenous estrogen and progesterone. To gain insight into the protective mechanism, fifteen 3-month old post-pubertal virgin Lewis rats were randomly assigned to three groups: control (C), pregnancy (P) or hormone (H). The P group animals underwent a full-term pregnancy and H group animals were implanted subcutaneously with silastic capsules filled with ethynyl estradiol and megesterol acetate for 21 days. C and P animals were implanted with sham capsules. On day 21 capsules were removed, which was followed by a 49-day involution period, euthanasia and mammary tissue collection. Global gene expression was measured using Rat Genome 230.2 Arrays. Histological analysis revealed that P and H treatments induced sustained morphological changes in the mammary gland with significantly increased the percentages of mammary parenchyma and stromal tissues and higher ratio of stroma to parenchyma. Transcriptome analysis showed that P and H treatments induced sustained global changes in gene expression in the mammary gland. Analysis of commonly up- and down- regulated genes in P and H relative to C treatment showed increased expression of three matrix metallopeptidases (Mmp3, 8 and 12), more differentiated mammary phenotype, enhanced innate and adaptive immunity and reduced cell proliferation and angiogenic signatures. The sustained morphological and global gene expression changes in mammary tissue after pregnancy and hormone treatment may function together to provide the protective effect against breast cancer. |
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Authors:
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Yogi Misra; Pamela A Bentley; Jeffery P Bond; Scott Tighe; Timothy Hunter; Feng-Qi Zhao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-15 |
Journal Detail:
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Title: Physiological genomics Volume: - ISSN: 1531-2267 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Vermont. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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