| Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. | |
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MedLine Citation:
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PMID: 20980442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells of the mammary gland are in intimate contact with other cells and with the extracellular matrix (ECM), both of which provide not only a biochemical context, but a mechanical context as well. Cell-mediated contraction allows cells to sense the stiffness of their microenvironment, and respond with appropriate mechanosignaling events that regulate gene expression and differentiation. ECM composition and organization are tightly regulated throughout development of the mammary gland, resulting in corresponding regulation of the mechanical environment and proper tissue architecture. Mechanical regulation is also at play during breast carcinoma progression, as changes in ECM deposition, composition, and organization accompany breast carcinoma. These changes result in stiffer matrices that activate mechanosignaling pathways and thereby induce cell proliferation, facilitate local tumor cell invasion, and promote progression. Thus, understanding the role of forces in the mammary gland is crucial to understanding both normal developmental and pathological processes. |
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Authors:
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Pepper Schedin; Patricia J Keely |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2011-01-01 |
Journal Detail:
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Title: Cold Spring Harbor perspectives in biology Volume: 3 ISSN: 1943-0264 ISO Abbreviation: Cold Spring Harb Perspect Biol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-07-15 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 101513680 Medline TA: Cold Spring Harb Perspect Biol Country: United States |
Other Details:
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Languages: eng Pagination: a003228 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Medical Oncology, University of Colorado, Denver, Colorado 80045, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Breast Neoplasms / physiopathology* Cell Differentiation / physiology* Cell Proliferation Collagen / metabolism Extracellular Matrix / metabolism* Female Fibronectins / metabolism Focal Adhesions / physiology Gene Expression Regulation / physiology* Humans Mammary Glands, Human / cytology* Mechanotransduction, Cellular / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 9007-34-5/Collagen |
| Comments/Corrections | |
Comment In:
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Cancer Cell. 2011 Sep 13;20(3):285-6
[PMID:
21907919
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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