Document Detail

Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression.
MedLine Citation:
PMID:  20980442     Owner:  NLM     Status:  MEDLINE    
Cells of the mammary gland are in intimate contact with other cells and with the extracellular matrix (ECM), both of which provide not only a biochemical context, but a mechanical context as well. Cell-mediated contraction allows cells to sense the stiffness of their microenvironment, and respond with appropriate mechanosignaling events that regulate gene expression and differentiation. ECM composition and organization are tightly regulated throughout development of the mammary gland, resulting in corresponding regulation of the mechanical environment and proper tissue architecture. Mechanical regulation is also at play during breast carcinoma progression, as changes in ECM deposition, composition, and organization accompany breast carcinoma. These changes result in stiffer matrices that activate mechanosignaling pathways and thereby induce cell proliferation, facilitate local tumor cell invasion, and promote progression. Thus, understanding the role of forces in the mammary gland is crucial to understanding both normal developmental and pathological processes.
Pepper Schedin; Patricia J Keely
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-01-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  3     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-15     Revised Date:  2013-10-24    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a003228     Citation Subset:  IM    
Department of Medicine, Division of Medical Oncology, University of Colorado, Denver, Colorado 80045, USA.
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MeSH Terms
Breast Neoplasms / physiopathology*
Cell Differentiation / physiology*
Cell Proliferation
Collagen / metabolism
Extracellular Matrix / metabolism*
Fibronectins / metabolism
Focal Adhesions / physiology
Gene Expression Regulation / physiology*
Mammary Glands, Human / cytology*
Mechanotransduction, Cellular / physiology*
Grant Support
Reg. No./Substance:
0/Fibronectins; 9007-34-5/Collagen
Comment In:
Cancer Cell. 2011 Sep 13;20(3):285-6   [PMID:  21907919 ]

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