Document Detail

Mammary Gland Development.
MedLine Citation:
PMID:  22844349     Owner:  NLM     Status:  Publisher    
The mammary gland develops through several distinct stages. The first transpires in the embryo as the ectoderm forms a mammary line that resolves into placodes. Regulated by epithelial/mesenchymal interactions, the placodes descend into the underlying mesenchyme and produce the rudimentary ductal structure of the gland present at birth. Subsequent stages of development - pubertal growth, pregnancy, lactation and involution - occur postnatally under the regulation of hormones. Puberty initiates branching morphogenesis, which requires growth hormone and estrogen, as well as IGF1, to create a ductal tree that fills the fat pad. Upon pregnancy the combined actions of progesterone and prolactin generate alveoli, which secrete milk during lactation. Lack of demand for milk at weaning initiates the process of involution whereby the gland is remodeled back to its pre-pregnancy state. These processes require numerous signaling pathways that have distinct regulatory functions at different stages of gland development. Signaling pathways also regulate a specialized subpopulation of mammary stem cells that fuel the dramatic changes in the gland occurring with each pregnancy. Our knowledge of mammary gland development and mammary stem cell biology has significantly contributed to our understanding of breast cancer and has advanced the discovery of therapies to treat this disease.
Hector Macias; Lindsay Hinck
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  Wiley interdisciplinary reviews. Developmental biology     Volume:  1     ISSN:  1759-7692     ISO Abbreviation:  Wiley Interdiscip Rev Dev Biol     Publication Date:  2012 7 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576624     Medline TA:  Wiley Interdiscip Rev Dev Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  533-557     Citation Subset:  -    
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064.
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