Document Detail


Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles.
MedLine Citation:
PMID:  23278901     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and survival. There is limited evidence that mTOR influences hair follicles (HFs), which undergo cycles of quiescence (telogen), growth (anagen) and regression (catagen). We sought to investigate whether mTOR, in particular mTOR complex 1 (mTORC1), regulates the hair growth cycle by employing biochemical, immunohistochemical and functional approaches in vivo. Here, we demonstrate that quantitative analysis of mTORC1 kinase activity shows phase-dependent changes, and phosphorylated mTOR at S2448 (p-mTOR) was localized in certain sites of HFs in a phase-dependent manner. These results were indicative of mTOR's role in hair growth initiation. Finally, in a pharmacological challenge in vivo using the specific mTORC1 inhibitor, rapamycin, hair cycle initiation was delayed, suggesting a functional relevance of mTORC1 in anagen entry. Based on our findings, we propose that mTORC1 may participate in hair cycle regulation, namely the timing of anagen initiation.
Authors:
Antonia J Kellenberger; Miyuki Tauchi
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Experimental dermatology     Volume:  22     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-27     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks
Hair / growth & development
Hair Follicle / drug effects,  metabolism*
Mice
Mice, Inbred C57BL
Multiprotein Complexes / metabolism*
Phosphorylation
Proteins / metabolism*
Ribosomal Protein S6 Kinases, 70-kDa / metabolism
Sirolimus / pharmacology
TOR Serine-Threonine Kinases / metabolism*
Chemical
Reg. No./Substance:
0/Multiprotein Complexes; 0/Proteins; 0/mechanistic target of rapamycin complex 1; 53123-88-9/Sirolimus; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.1.1/mTOR protein, mouse; EC 2.7.11.1/Ribosomal Protein S6 Kinases, 70-kDa

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