| Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | |
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MedLine Citation:
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PMID: 11274345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The molecular details of mammalian stress-activated signal transduction pathways have only begun to be dissected. This, despite the fact that the impact of these pathways on the pathology of chronic inflammation, heart disease, stroke, the debilitating effects of diabetes mellitus, and the side effects of cancer therapy, not to mention embryonic development, innate and acquired immunity, is profound. Cardiovascular disease and diabetes alone represent the most significant health care problems in the developed world. Thus it is not surprising that understanding these pathways has attracted wide interest, and in the past 10 years, dramatic progress has been made. Accordingly, it is now becoming possible to envisage the transition of these findings to the development of novel treatment strategies. This review focuses on the biochemical components and regulation of mammalian stress-regulated mitogen-activated protein kinase (MAPK) pathways. The nuclear factor-kappa B pathway, a second stress signaling paradigm, has been the subject of several excellent recent reviews (258, 260). |
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Authors:
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J M Kyriakis; J Avruch |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Physiological reviews Volume: 81 ISSN: 0031-9333 ISO Abbreviation: Physiol. Rev. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-29 Completed Date: 2001-04-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0231714 Medline TA: Physiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 807-69 Citation Subset: IM |
Affiliation:
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Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02129, USA. kyriakis@helix.mgh.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / physiology Humans Inflammation / physiopathology* MAP Kinase Signaling System / physiology* Mammals Mitogen-Activated Protein Kinases / metabolism* Stress, Physiological / physiopathology* p38 Mitogen-Activated Protein Kinases |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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