Document Detail

Mammalian isovalthine metabolism.
MedLine Citation:
PMID:  19112709     Owner:  NLM     Status:  MEDLINE    
Isovalthine is a branched-chain sulphur amino acid, which has been found in the urine of normal cats. The concentrations of isovalthine in the urine of healthy adult cats are approximately 24-66 micromol/l and are not affected by the gender of the cat. Isovalthinuria can be induced in other species (rats, rabbits, guinea-pigs, humans, dogs) following the administration of certain inducing agents such as some hypocholesterolaemic agents, bile acids, hormones or cholesterol precursors. The method of induction of isovalthinuria was studied extensively during the 1960s, and efforts were made to understand its biosynthesis. However, although the origin of the sulphur atom in isovalthine was shown to be from cysteine or methionine, the origin of the carbon skeleton remains unknown. Interest in isovalthine metabolism was generated in part because it was reportedly found in the urine of patients with hypercholesterolaemia. The validity of this finding however, was brought into question following reports that administration of the drug Bromural (alpha-bromoisovalerylurea), to humans results in the generation of compounds which break down to yield isovalthine following acid hydrolysis. This article presents a review and discussion of the experimental data on isovalthine metabolism.
K J Rutherfurd-Markwick; Q R Rogers; W H Hendriks
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of animal physiology and animal nutrition     Volume:  89     ISSN:  0931-2439     ISO Abbreviation:  J Anim Physiol Anim Nutr (Berl)     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2008-12-30     Completed Date:  2009-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126979     Medline TA:  J Anim Physiol Anim Nutr (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
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MeSH Terms
Biological Markers / urine
Cystine / analogs & derivatives*,  chemistry,  metabolism
Guinea Pigs
Hypercholesterolemia / urine*
Species Specificity
Reg. No./Substance:
0/2-amino-5-carboxy-6-methyl-4-thiaheptanoic acid; 0/Biological Markers; 56-89-3/Cystine

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