Document Detail


MAMMALIAN IRON HOMEOSTASIS IN HEALTH AND DISEASE: UPTAKE, STORAGE, TRANSPORT AND MOLECULAR MECHANISMS OF ACTION.
MedLine Citation:
PMID:  23199217     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Iron is a crucial factor for life. However it also has the potential to cause the formation of noxious free radicals. These "double-edged sword"characteristics demand a tight regulation of cellular iron metabolism. In this review we discuss the various pathways of cellular iron uptake, cellular iron storage and transport. Recent advances in understanding the reduction and uptake of non-transferrin-bound iron are discussed. We also discuss recent progress in the understanding of transcriptional and translational regulation by iron. Furthermore we discuss recent advances in the understanding of the regulation of cellular and systemic iron homeostasis and several key diseases resulting from iron deficiency and overload. We discuss the knockout mice available for studying iron metabolism and the related human conditions.
Authors:
Alfons Lawen; Darius John Rowland Lane
Related Documents :
24445237 - Citrate - new functions for an old metabolite.
23478817 - Farm and pig factors affecting welfare during the marketing process.
24160757 - Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizi...
23223517 - Altered udp-glucuronosyltransferase and sulfotransferase expression and function during...
11374537 - Effects of surgical catheterization and degree of isolation on the behavior and exocrin...
3019727 - Interference of bn 52021 (ginkgolide b) with the bronchopulmonary effects of paf-acethe...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-2
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Monash university, Biochemistry and Molecular Biology, Bldg 13D, N/A, Victoria, Australia, 3800, (03)9905 3711, (03)9902 9500; Alfons.Lawen@monash.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Discrimination Concerns and Expectations as Explanations for Gendered Socialization in African Ameri...
Next Document:  Cross-sectional and longitudinal associations between parenting style and adolescent girls' physical...