Document Detail


Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.
MedLine Citation:
PMID:  15922018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Flavin-containing monooxygenase (FMO) oxygenates drugs and xenobiotics containing a "soft-nucleophile", usually nitrogen or sulfur. FMO, like cytochrome P450 (CYP), is a monooxygenase, utilizing the reducing equivalents of NADPH to reduce 1 atom of molecular oxygen to water, while the other atom is used to oxidize the substrate. FMO and CYP also exhibit similar tissue and cellular location, molecular weight, substrate specificity, and exist as multiple enzymes under developmental control. The human FMO functional gene family is much smaller (5 families each with a single member) than CYP. FMO does not require a reductase to transfer electrons from NADPH and the catalytic cycle of the 2 monooxygenases is strikingly different. Another distinction is the lack of induction of FMOs by xenobiotics. In general, CYP is the major contributor to oxidative xenobiotic metabolism. However, FMO activity may be of significance in a number of cases and should not be overlooked. FMO and CYP have overlapping substrate specificities, but often yield distinct metabolites with potentially significant toxicological/pharmacological consequences. The physiological function(s) of FMO are poorly understood. Three of the 5 expressed human FMO genes, FMO1, FMO2 and FMO3, exhibit genetic polymorphisms. The most studied of these is FMO3 (adult human liver) in which mutant alleles contribute to the disease known as trimethylaminuria. The consequences of these FMO genetic polymorphisms in drug metabolism and human health are areas of research requiring further exploration.
Authors:
Sharon K Krueger; David E Williams
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacology & therapeutics     Volume:  106     ISSN:  0163-7258     ISO Abbreviation:  Pharmacol. Ther.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2006-08-18     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7905840     Medline TA:  Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-87     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Humans
Molecular Sequence Data
Molecular Structure
Oxygenases / chemistry,  genetics*,  metabolism*
Pharmaceutical Preparations / chemistry,  metabolism*
Polymorphism, Genetic*
Structure-Activity Relationship
Substrate Specificity
Grant Support
ID/Acronym/Agency:
P30 ES000210/ES/NIEHS NIH HHS; R01 HL038650/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations; EC 1.13.-/Oxygenases; EC 1.14.13.8/dimethylaniline monooxygenase (N-oxide forming)
Comments/Corrections

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